Cell–cell and cell–matrix interactions

نویسندگان

  • Kris A. DeMali
  • Josephine C. Adams
چکیده

Roles of cell protrusions as initial and dynamic mediators of cell–cell and cell–ECM interactions Filopodia have well-established roles in sampling the local environment and making initial cell–ECM contacts at the leading edge of many cell types. Filopodial-like structures, termed “epithelial zippers,” can mediate initial contacts between epithelial cells that culminate in assembly of cell–cell junctions. However, the molecular composition of these structures and their relationship to filopodia has remained unclear. Katy Liu from Richard Cheney’s laboratory (University of North Carolina at Chapel Hill) showed localization of myosin-X in initial, filopodial contacts between epithelial cells. Whereas myosin-X has a known role in filopodial assembly, the data presented revealed additional important functions in assembly of cell–cell junctions and epithelial morphogenesis. Brad Davidson (University of Arizona) presented data from Ciona intestinalis embryos, a tractable system for the analysis of cell specification in an intact organism (Cooley et al., 2011). Specification of precardiac cells is directed by polarized, invasive filopodial protrusions that localize their response to an ungraded signal.

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عنوان ژورنال:

دوره 23  شماره 

صفحات  -

تاریخ انتشار 2012